Great dive bar that's been around forever. I lived down the street for years when i was in college and did not appreciate it! The slightly older late 20s/30s that hung out there at the time hated me and all my friends for turning 21 and being a mess in there. It wasn't until I left and came back that i realized what had been right there in front of me. Youth wasted yet again. Anyway, they have some 600 whiskies and similar number of beers. They have a ton of special casks that disteraries make just for them. Incredible punk filled jukebox. Iconic. Be sure to have Malört at some point, there or elsewhere, do not google it, just do it.
The River Architecture boat tour is a classic if it's warm enough.
MCA and Art Institute are both worth a visit as well.